To be more specific: I am running Windows 10 21H2, and have gotten the P6x58d-e up and running pretty well, except for this problem: the USB Ports 5/6 and 7/8 are not working. They are sending power to USB devices (mice, etc.) but not transmitting any info (I am speaking specifically about the ones that connect to a breakout board to the back of the chassis, and going to two ports at the front of the chassis).\n\nThe USB 2.0 ports that come out of the Rear Panel (1/2 and 3/4) all work fine (as does USB 3.0).\n\nIn looking at Device Manager, it is saying that I the system is having trouble updating drivers for Intel ICH10 Family USB Universal Host Controller ("The driver installation file for this device is missing a necessary entry.") I am thinking that this is somehow related to the issue I'm dealing with, but I am scared to start replacing any Southbridge drivers I presently have up and running (and I am assuming the NB/SB drivers are all Win7, seeing as that's the most recent ones written (yes? no?), with any other driver, the effects of which I don't yet fully understand, and in so doing exchange a pretty good situation with a much worse situation, due to unexpected results.\n\n I was wondering if anybody out there has had anything like this trouble, and how you overcame it, if you did?