yes. I am running an older selection of DDR that I had hanging around that does not live up to the Corsair XMS3500 specs but is good Mushkin none the less. With everything set stock, that is, the NB set to by cpu and the cpu not on a user define and the ram timings on advanced chipset settings at by spd, the system runs in ddr266 and dual channel mode. I can't speak for the 333 speed...